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Meta-analysis: area under ROC curve

Command:Statistics
Next selectMeta-analysis
Next selectArea under ROC curve

Description

For a short overview of meta-analysis in MedCalc, see Meta-analysis: introduction.

MedCalc uses the methods described by Zhou et al. (2002) for calculating the weighted summary Area under the ROC curve under the fixed effects model and random effects model.

How to enter data

The data of different studies can be entered as follows in the spreadsheet (example taken from Zhou et al., 2002):

Meta-analysis: area under ROC curve - how to enter data

Required input

The dialog box for "Meta-analysis: area under ROC curve" can then be completed as follows:

Meta-analysis: area under ROC curve - dialog box

Studies: a variable containing an identification of the different studies.

Data

Area under ROC curve (AUC): a variable containing the Area under the ROC curve reported in the different studies.

Standard error of AUC: a variable containing the Standard error of the Area under the ROC curve reported in the different studies.

Filter: a filter to include only a selected subgroup of cases in the graph.

Options

Results

Meta-analysis: area under ROC curve - results

The program lists the results of the individual studies included in the meta-analysis: the area under the ROC curve, its standard error and 95% confidence interval.

The pooled Area under the ROC curve with 95% CI is given both for the Fixed effects model and the Random effects model (Zhou et al., 2002).

The random effects model will tend to give a more conservative estimate (i.e. with wider confidence interval), but the results from the two models usually agree where there is no heterogeneity. See Meta-analysis: introduction for interpretation of the heterogeneity statistics Cohran's Q and I2. When heterogeneity is present the random effects model should be the preferred model.

See Meta-analysis: introduction for interpretation of the different publication bias tests.

Forest plot

The results of the different studies, with 95% CI, and the pooled Area under the ROC curve with 95% CI are shown in a forest plot:

Meta-analysis: area under ROC curve - forest plot

Literature

See also

Recommended book

Introduction to Meta-Analysis
Michael Borenstein, Larry V. Hedges, Julian P. T. Higgins, Hannah R. Rothstein

Buy from Amazon US - CA - UK - DE - FR - ES - IT

This book provides a clear and thorough introduction to meta-analysis, the process of synthesizing data from a series of separate studies. Meta-analysis has become a critically important tool in fields as diverse as medicine, pharmacology, epidemiology, education, psychology, business, and ecology.