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The relative risk (RR), its standard error and 95% confidence interval are calculated according to Altman, 1991.
The relative risk or risk ratio is given by
with the standard error of the log relative risk being
and 95% confidence interval
Where zeros cause problems with computation of the relative risk or its standard error, 0.5 is added to all cells (a, b, c, d) (Pagano & Gauvreau, 2000; Deeks & Higgins, 2010).
Number Needed to Treat (NNT)
The number needed to treat (NNT) is the estimated number of patients who need to be treated with the new treatment rather than the standard treatment (or no treatment) for one additional patient to benefit (Altman 1998).
A negative number for the number needed to treat has been called the number needed to harm.
MedCalc uses the terminology suggested by Altman (1998) with NNT(Benefit) and NNT(Harm) being the number of patients needed to be treated for one additional patient to benefit or to be harmed respectively.
The 95% confidence interval is calculated according to Daly (1998) and is reported as suggested by Altman (1998).
- Altman DG (1991) Practical statistics for medical research. London: Chapman and Hall.
- Altman DG (1998) Confidence intervals for the number needed to treat. British Medical Journal 317: 1309-1312. [Abstract]
- Daly LE (1998) Confidence limits made easy: interval estimation using a substitution method. American Journal of Epidemiology 147: 783-790. [Abstract]
- Deeks JJ, Higgins JPT (2010) Statistical algorithms in Review Manager 5. Retrieved from http://ims.cochrane.org/revman/documentation/Statistical-methods-in-RevMan-5.pdf
- Pagano M, Gauvreau K (2000) Principles of biostatistics. 2nd ed. Belmont, CA: Brooks/Cole.
- Parshall MB (2013) Unpacking the 2 x 2 table. Heart & Lung 42:221-226. [Abstract]