# Sample size calculation: Survival analysis (logrank test)

Command: | Sample size Survival analysis (logrank test) |

## Description

Calculates the required sample size for the comparison of survival rates in two independent groups.

## Required input

- Type I error - alpha: the probability of making a Type I error (α-level, two-sided), i.e. the probability of rejecting the null hypothesis when in fact it is true.
- Type II error - beta: the probability of making a Type II error (β-level), i.e. the probability of accepting the null hypothesis when in fact it is false.
- Survival rate Group 1: the hypothesized survival rate in the first group.
- Survival rate Group 2: the hypothesized survival rate in the second group.
- Ratio of sample sizes in Group 1 / Group 2: the ratio of the sample sizes in group 1 and 2. Enter 1 for equal sample sizes in both groups. Enter 2 if the number of cases in group 1 must be double of the number of cases in group 2.

## Example

You are interested in detecting a difference between survival rates of 0.6 and 0.4. You plan to have twice as many cases in the first group as in the second group.

For α-level you select 0.05 and for β-level you select 0.20 (power is 80%).

Enter the values 0.6 and 0.4 for the Survival rates in Group 1 and Group 2, and enter 2 for the Ratio of sample sizes.

## Results

After you click Calculate the program displays the required sample size.

In the example 129 cases are required in Group 1 and 65 cases in Group 2, giving a total of 194 cases.

A table shows the required total sample size for different Type I and Type II Error levels.

## Literature

- Machin D, Campbell MJ, Tan SB, Tan SH (2009) Sample size tables for clinical studies. 3
^{rd}ed. Chichester: Wiley-Blackwell.

## See also

## Recommended book

## Sample Size Tables for Clinical Studies

David Machin, Michael J. Campbell, Say-Beng Tan, Sze-Huey Tan

Buy from Amazon