MedCalc installation on a Mac using Wine
Install MedCalc using Wine on Mac
Open the Terminal application on your Mac.
Install Homebrew (if not already installed) by running the following command:
/bin/bash -c "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/HEAD/install.sh)"
Once Homebrew is installed, update it by running:
brew update
Install the stable version of Wine using Homebrew:
brew install --cask --no-quarantine wine-stable
If you do not already have it, install wget:
brew install wget
First install the Arial font (MedCalc will work much better with this font).
wget https://sget.nl/arial32.exe wine arial32.exe
Next, get the MedCalc installer:
wget https://www.medcalc.org/download/medcalcsetup64.exe
Start the installer:
wine medcalcsetup64.exe
and complete the MedCalc setup wizard.
An icon 'MedCalc.lnk' will be displayed on the desktop. You can use this to start MedCalc.
How to create a macOS Launchpad icon for MedCalc
You need to wrap the EXE in a tiny macOS App Bundle:
- Go to Applications in Finder and open the Automator app.
- Click New Document
- Choose Application
- Double-click “Run Shell Script” (shown in the 2nd column)
- Add the following script, replacing YOURNAME with your Mac user name (the one you see in the Users folder).
/usr/local/bin/wine "/Users/YOURNAME/.wine/drive_c/Program Files/MedCalc/medcalc.exe"
- Save the app in Applications (File - Save ...)

Launchpad will show MedCalc - but not using the MedCalc icon.
To assign the correct icon to the app:
- Copy the desired icon image to the clipboard. You can find a MedCalc icon in
/Users/YOURNAME/.wine/drive_c/Program Files (x86)/MedCalc/
or you click the following icon to save it in your downloads folder:
- In Finder, goto Applications
- Get Info on the MedCalc application
- In the dialog box, click the current icon in the upper left of the dialog box, and then paste the new image using command-v
Wine configuration - Registry editor
Use the command winecfg in Terminal for additional Wine configurations, and regedit for the registry editor.
Important: in winecfg, on the Drives tab, do not change the path for the z: drive. It must point to /
Make text in user interface larger
You may find that the text used in the MedCalc user interface is too small.
To enlarge, use winecfg in Terminal. In the dialog box, on the Graphics tab, enlarge the Screen resolution.

Close the dialog box and restart MedCalc.
How to remove a Windows program from Wine
To uninstall a program use the following command in Terminal:
wine uninstaller
In the dialog box, you can select the programs you want to uninstall:

How to uninstall Wine and Homebrew from your Mac
To uninstall Wine, use the following command in Terminal:
brew uninstall --cask wine-stable
To remove Homebrew, use:
/bin/bash -c "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/HEAD/uninstall.sh)"